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Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus
(Turk Neurosurg, 2018-04-24)
AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth
factor 1 (IGF-1)/bone morphogenetic protein (BMP)-2 following intervertebral disc ...
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
(Experimental and Therapeutic Medicine, 2019-02-28)
The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells invitro. ...
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
(Experimental and Therapeutic Medicine, 2019-02-06)
The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ...
Are Intervertebral Disc Tissue Cells Damaged When Attempting to Prevent Thrombus Formation Using Dabigatran, A New Oral Anticoagulant?
(Turk Neurosurg, 2019-05-22)
AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell cultures isolated from intact
intervertebral disc tissue.
MATERIAL and METHODS: Cell cultures were prepared from tissues ...
Evaluation of the Effect of Daptomycin, a Glycopeptide Agent, on Intact Intervertebral Disc Tissue
(Turk Neurosurg, 2019-02-28)
AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral
disc tissue cells.
MATERIAL and METHODS: Primary cell cultures were established using ...
Are Specific Gene Expressions of Extracellular Matrix and Nucleus Pulposus Affected by Primary Cell Cultures Prepared from Intact or Degenerative Intervertebral Disc Tissues?
(Turk Neurosurg, 2018-02-26)
AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact
tissues.
MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ...
Does Nimodipine, a Selective Calcium Channel Blocker, Impair Chondro-cyte Proliferation or Damage Extracellular Matrix Structures?
(Current Pharmaceutical Biotechnology, 2019-04-17)
Background:
The study aimed to investigate the effects of the active ingredient, nimodipine, on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue cells.
Methods:
Chondrocyte ...
Investigation of the Effects of Methylphenidate, an Amphetamine Derivative, on Intervertebral Disc Tissue Cell Cultures and Matrix Structures
(Turk Neurosurg, 2019-07-24)
AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix
structures. Changes in the expression of some important marker genes involved in anabolic ...
Which pharmacological agents may be used to establish healthy, proliferating human primer nucleus pulposus / annulus fibrosus cell cultures? Systematic evaluation of our experience in the light of literature
(Merit Research Journal of Medicine and Medical Sciences, 2018-03)
Intervertebral disc tissue is damaged and loses its normal physiological
functions due to age-related degeneration, vigorous physical activity and
trauma in all age groups and at any stage of life. Here we aim to present ...
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
(Experimental and Therapeutic Medicine, 2018-03-23)
The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clini-cians, exert toxic effects on human primary ...