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Delivering Growth Factors through a Polymeric Scaffold to Cell Cultures Containing both Nucleus Pulposus and Annulus Fibrosus
(Turk Neurosurg, 2018-04-24)
AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth
factor 1 (IGF-1)/bone morphogenetic protein (BMP)-2 following intervertebral disc ...
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
(Experimental and Therapeutic Medicine, 2019-02-28)
The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells invitro. ...
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
(Experimental and Therapeutic Medicine, 2019-02-06)
The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ...
Are Specific Gene Expressions of Extracellular Matrix and Nucleus Pulposus Affected by Primary Cell Cultures Prepared from Intact or Degenerative Intervertebral Disc Tissues?
(Turk Neurosurg, 2018-02-26)
AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact
tissues.
MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ...
Which pharmacological agents may be used to establish healthy, proliferating human primer nucleus pulposus / annulus fibrosus cell cultures? Systematic evaluation of our experience in the light of literature
(Merit Research Journal of Medicine and Medical Sciences, 2018-03)
Intervertebral disc tissue is damaged and loses its normal physiological
functions due to age-related degeneration, vigorous physical activity and
trauma in all age groups and at any stage of life. Here we aim to present ...
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
(Experimental and Therapeutic Medicine, 2018-03-23)
The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clini-cians, exert toxic effects on human primary ...
Are radio‐contrast agents commonly used in discography toxicto the intact intervertebral disc tissue cells?
(Basic Clinical Pharmacology Toxicology, 2018-08-13)
In the literature, there have been no studies showing clear results on how radio‐contrast pharmaceuticals would affect intact disc tissue cells. In this context, itwas aimed to evaluate the effects of iopromide and gadoxetic ...
Will it be possible to prevent lumbar degenerative disc diseases in the future by means of vitamin D receptor gene manipulation?
(Merit Research Journal of Medicine and Medical Sciences, 2017-10)
It is primarily aimed to study polymorphisms in vitamin D receptor gene (VDR), which is one of the genetic
factors having a role in the formation of lumbar pathologies and/or causing higher incidence of pathologic
processes. ...
Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
(Experimental and Therapeutic Medicine, 2018-05-11)
Non‑steroidal anti‑inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine ...
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1α, Chondroadherin, and COL2A1?
(Annals of Medical Research, 2018)
Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-
administered primary chondrocyte cultures and non-drug-administered primary chondrocyte ...