Will it be possible to prevent lumbar degenerative disc diseases in the future by means of vitamin D receptor gene manipulation?
Date
2017-10Author
Karaarslan, Numan
Kaya, Yasin Emre
Yılmaz, İbrahim
Özbek, Hanefi
Bilir, Betül Ekiz
Kaplan, Necati
Şirin, Duygu Yaşar
Akyuva, Yener
Gürbüz, Mehmet Sabri
Özman, Kadir
Akkaya, Semih
Mutlu, Çağrı Ata
Güler, Olcay
Ateş, Özkan
Mahiroğulları, Mahir
Metadata
Show full item recordAbstract
It is primarily aimed to study polymorphisms in vitamin D receptor gene (VDR), which is one of the genetic
factors having a role in the formation of lumbar pathologies and/or causing higher incidence of pathologic
processes. Secondarily, it is aimed to create pre-data which may help professionals to administer more
effective and protective interventions in this area. Without any language preference, we searched US National
Library of Medicine National Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials
from 1989 to Mar 11 to 2017 Mar 12, and traced all the references of incorporated documents. The data were
evaluated by using descriptive statistics. Results were shown as amount or frequency (%). In literature, some
vitamin D receptor gene (VDR) polymorphisms have been found in relation to widespread osteochondral
diseases. When VDR polymorphisms, vitamin D level and intervertebral disc pathologies have been examined, a
satisfactory answer to the question whether specific pathologies could be suppressed in terms of genetics has
not been found. By means of this study, it would be understood the genetic factors inhibiting physio
pathological process concerning lumbar degenerative disc disease or the genetic factors playing role in
identifying physio pathological process related to lumbar degenerative disc disease by defining them.
Accordingly, effective and contraceptive treatment of lumbar degenerative disc disease might be ensured soon.
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